Casa Pia beat Sporting Covilhã 1-0 on Saturday in a Round 24 game in Liga 2, and are the lone leaders after Benfica B drew the day before.
João Vieira, who had come off the bench a minute earlier, scored the decisive goal in the 85th minute.
Casa Pia thus has 49 points, two more than the reds, who lost a draw against Chaves.
Covilhã remains in the hold-off position, in 16th place, with 19 points.